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Article

Pathophysiology of vascular calcification: Pivotal role of cellular senescence in vascular smooth muscle cells.

Experimental gerontology - 1 Nov 2010

Burton D G A, Matsubara H, Ikeda K

Abstract excerpt

The accumulation of senescent cells within tissues can potentially lead to biological dysfunction and manifestation of disease associated with ageing. The majority of senescent cells display a commonly altered secretome similar to a wound healing response (termed the senescence-associated secretory phenotype or SASP), which could have deleterious implications on the tissue microenvironment. However, senescent...

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Identifiers

PMID: 20647039
DOI: 10.1016/j.exger.2010.07.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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