Article

<i>In vitro</i> and <i>in vivo</i> CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain

2021-11-23

Abstract excerpt

Aging impairs the ability of neural stem cells to transition from quiescence to activation (proliferation) in the adult mammalian brain. Neural stem cell (NSC) functional decline results in decreased production of new neurons and defective regeneration upon injury during aging 1–9 , and this is exacerbated in Alzheimer’s disease 10 . Many genes are upregulated with age in NSCs 3, 11–13 , and the knockout of som...

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Literature Corpus work: abd12612-e40c-54b5-9884-7d2b7a3131d8
DOI: 10.1101/2021.11.23.469762

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