Article
Loss-of-function Mutations of CUL3, a High Confidence Gene for Psychiatric Disorders, Lead to Aberrant Neurodevelopment In Human Induced Pluripotent Stem Cells.
Neuroscience - 10 Nov 2020
Fischer Sandra, Schlotthauer Ines, Kizner Valeria, Macartney Thomas, Dorner-Ciossek Cornelia, Gillardon Frank
Abstract excerpt
Both rare, high risk, loss-of-function mutations and common, low risk, genetic variants in the CUL3 gene are strongly associated with neuropsychiatric disorders. Network analyses of neuropsychiatric risk genes have shown high CUL3 expression in the prenatal human brain and an enrichment in neural precursor cells (NPCs) and cortical neurons. The role of CUL3 in human neurodevelopment however, is poorly understood....
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