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Spatial transcriptomics reveals ovarian cancer subclones with distinct tumour microenvironments

2022-08-29

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is characterised by recurrence, chemotherapy resistance and overall poor prognosis. Genetic heterogeneity of tumour cells and the microenvironment of the tumour have been hypothesised as key determinants of treatment resistance and relapse. Here, using a combination of spatial and single cell transcriptomics (10x Visium and Chromium platforms), we examine tumour genetic...

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Literature Corpus work
fc6f7405-3b74-53f8-8bfd-4b37d28dc509
DOI
10.1101/2022.08.29.505206
Open publication

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Spatial transcriptomics reveals ovarian cancer subclones with distinct tumour microenvironmentsDOI 10.1101/2022.08.29.505206
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