Article

A single-nucleus multimodal framework reveals epigenomic priming of chemoresistant states in ovarian cancer

2025-12-08

Abstract excerpt

Non-genetic intratumor heterogeneity (ITH) drives therapeutic failure in cancer, yet its clinical monitoring remains challenging. We develop a multimodal single-nucleus framework that simultaneously profiles transcriptional and histone modification landscapes from frozen biopsies. Applied to longitudinal samples from 16 patients with high-grade serous ovarian cancer (HGSOC), this approach reveals reproducible tumo...

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Literature Corpus work: 71de3f5b-501a-5b08-b3c1-b94d3ce44742
DOI: 10.64898/2025.12.04.692102

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