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<em>In Silico</em> and<em> In Vitro </em>Study towards the Rational Design of 4,4′-Disarylbisthiazoles as a Selective<em> α</em>-Synucleinopathy Biomarker

2023-10-25

Abstract excerpt

The α-synucleinopathies are a group of neurodegenerative diseases characterized by the deposition of α-synuclein aggregates (α-syn) in the brain. Currently, there is no suitable tracer to enable a definitive early diagnosis of these diseases. We reported candidates based on 4,4&#039;-disarylbisthiazole (DABTA) scaffold with a high affinity towards α-syn and excellent selectivity over Aβ and tau fibrils. Based on p...

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Literature Corpus work
abafbcdf-7875-57d2-b27d-6e42b27b66e8
DOI
10.20944/preprints202310.1592.v1
Open publication

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<em>In Silico</em> and<em> In Vitro </em>Study towards the Rational Design of 4,4′-Disarylbisthiazoles as a Selective<em> α</em>-Synucleinopathy BiomarkerDOI 10.20944/preprints202310.1592.v1
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