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Article

In Silico, in Vitro, and in Vivo Evaluation of New Candidates for α-Synuclein PET Imaging

10 Jul 2018

Abstract excerpt

Accumulation of α-synuclein (α-syn) is a neuropathological hallmark of synucleinopathies. To date, no selective α-syn positron emission tomography (PET) radiotracer has been identified. Our objective was to develop the first original, selective, and specific α-syn PET radiotracer. Chemical design inspired from three structural families that demonstrated interesting α-syn binding characteristics was used as a...

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PMID: 29989823
DOI: 10.1021/acs.molpharmaceut.8b00229

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