Article

A 2D Fragment-Assisted Protein Mimetic Approach to Rescue α-Synuclein Aggregation Mediated Early and Post-Disease Parkinson’s Phenotypes

2022-07-27

Abstract excerpt

<title>Abstract</title> <p>We have developed a Oligopyridylamide (OP) based 2-Dimensional Fragment-Assisted Structure-based Technique (2D-FAST) to identify potent antagonists of α-Synuclein (αS) aggregation, a process central to Parkinson’s disease (PD). The 2D-FAST utilizes a fragment-based screening of large chemical space in OPs, which led to the identification of NS132 as an antagonist of the multiple facets...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54796d8a-aa6d-59cb-ad89-2a2d8ebebfdc
DOI: 10.21203/rs.3.rs-1850943/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A 2D Fragment-Assisted Protein Mimetic Approach to Rescue α-Synuclein Aggregation Mediated Early and Post-Disease Parkinson’s PhenotypesDOI 10.21203/rs.3.rs-1850943/v1Read

A 2D Fragment-Assisted Protein Mimetic Approach to Rescue α-Synuclein Aggregation Mediated Early and Post-Disease Parkinson’s PhenotypesSemantic proximity Read

Protein mimetic 2D FAST rescues alpha synuclein aggregation mediated early and post disease Parkinson's phenotypes.Semantic proximity Read

Library-Derived Peptide Aggregation Modulators of Parkinson's Disease Early-Onset α-Synuclein Variants.Semantic proximity Read

Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-AssemblySemantic proximity Read

Foldamers rescue synucleinopathy phenotypes in multiple in vitro and in vivo models.Semantic proximity Read

“Common-Precursor” Protein Mimetic Approach to Rescue Aβ Aggregation-Mediated Alzheimer’s PhenotypesSemantic proximity Read

Mitigating protein aggregation to reduce the toxicity inherent to Parkinson's and Alzheimer's diseasesSemantic proximity Read

De novo designed protein inhibitors of amyloid aggregation and seedingSemantic proximity Read

Direct disassembly of α-syn preformed fibrils into native α-syn monomers by an all-D-peptideSemantic proximity Read

A <i>de novo</i> compound targeting α-synuclein improves deficits in models of Parkinson's diseaseSemantic proximity Read

Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and HealthspanSemantic proximity Read

AI-Guided Dual Strategy for Peptide Inhibitor Design Targeting Structural Polymorphs of α-Synuclein FibrilsSemantic proximity Read