Article

A 2D Fragment-Assisted Protein Mimetic Approach to Rescue α-Synuclein Aggregation Mediated Early and Post-Disease Parkinson’s Phenotypes

2022-07-13

Abstract excerpt

<h4>ABSTRACT</h4> We have developed a Oligopyridylamide (OP) based 2-Dimensional Fragment-Assisted Structure-based Technique (2D-FAST) to identify potent antagonists of α-Synuclein (αS) aggregation, a process central to Parkinson’s disease (PD). The 2D-FAST utilizes a fragment-based screening of large chemical space in OPs, which led to the identification of NS132 as an antagonist of the multiple facets of αS agg...

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Literature Corpus work: f4f61ff8-48ff-583f-bb48-d3443de374eb
DOI: 10.1101/2022.07.11.499659

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