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Article

Protein mimetic 2D FAST rescues alpha synuclein aggregation mediated early and post disease Parkinson's phenotypes.

Nature communications - 30 Apr 2024

Stillman Nicholas H, Joseph Johnson A, Ahmed Jemil, Baysah Charles Zuwu, Dohoney Ryan A, Ball Tyler D, Thomas Alexandra G, Fitch Tessa C, Donnelly Courtney M, Kumar Sunil

Abstract excerpt

Abberent protein-protein interactions potentiate many diseases and one example is the toxic, self-assembly of α-Synuclein in the dopaminergic neurons of patients with Parkinson's disease; therefore, a potential therapeutic strategy is the small molecule modulation of α-Synuclein aggregation. In this work, we develop an Oligopyridylamide based 2-dimensional Fragment-Assisted Structure-based Technique to identify...

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Identifiers

PMID: 38688913
DOI: 10.1038/s41467-024-47980-4
PMCID: PMC11061149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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