Article

A genetic regulatory map of human synovium and fat pad across the osteoarthritis spectrum

2026-07-31

Abstract excerpt

Osteoarthritis (OA) is increasingly recognized as a whole-joint disease, yet eQTL studies have focused almost exclusively on cartilage. Here we build cell-type-resolved gene regulatory maps of human synovium and infrapatellar fat pad (IPFP), integrating whole-genome sequencing and bulk transcriptomics (synovium n=138, IPFP n=70 donors) spanning joint-disease-free donors to severe OA, with single-nucleus multiomics...

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Literature Corpus work: aba6894c-6849-5771-bab5-3dfcc5422a97
DOI: 10.64898/2026.07.27.26358831

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