Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single cell transcriptome profiling of infrapatellar fat pad highlights the role of interstitial inflammatory fibroblasts in osteoarthritis

23 Mar 2024

Abstract excerpt

OBJECTIVES: Osteoarthritis (OA) is a whole-joint disease in which the role of the infrapatellar fat pad (IFP) in its pathogenesis is unclear. Our study explored the cellular heterogeneity of IFP to understand OA and identify therapeutic targets. METHODS: Single-cell and single-nuclei RNA sequencing were used to analyze 10 IFP samples, comprising 5 from OA patients and 5 from healthy controls. Analyses included...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesenchymal stem cell research
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38522139
DOI: 10.1016/j.intimp.2024.111888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single cell transcriptome profiling of infrapatellar fat pad highlights the role of interstitial inflammatory fibroblasts in osteoarthritisPMID 38522139Read ↗

Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee OsteoarthritisSemantic proximity Read ↗

Cell and transcriptomic diversity of infrapatellar fat pad during knee osteoarthritisSemantic proximity Read ↗

Cellular and molecular changes in the human osteoarthritic and aging hip pulvinarSemantic proximity Read ↗

Infrapatellar fat pad adipose tissue-derived macrophages display a predominant CD11c+CD206+ phenotype and express genotypes attributable to key features of OA pathogenesis.Semantic proximity Read ↗

An integrated single cell and spatial transcriptomic map of human white adipose tissueSemantic proximity Read ↗

CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis.Semantic proximity Read ↗

A genetic regulatory map of human synovium and fat pad across the osteoarthritis spectrumSemantic proximity Read ↗

Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integrationSemantic proximity Read ↗

Comprehensive analysis on subchondral bone marrow lesions of human osteoarthritis by integrating bulk and single-cell transcriptomesSemantic proximity Read ↗

From cells to clinic: Single-cell transcriptomics shaping the future of orthopedicsSemantic proximity Read ↗

Single-cell profiling uncovers synovial fibroblast subpopulations associated with chondrocyte injury in osteoarthritisSemantic proximity Read ↗

Dynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging processSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.