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Article

A landscape of gene expression regulation for synovium in arthritis.

Nature communications - 15 Feb 2024

Jiang Feng, Hu Shou-Ye, Tian Wen, Wang Nai-Ning, Yang Ning, Dong Shan-Shan, Song Hui-Miao, Zhang Da-Jin, Gao Hui-Wu, Wang Chen, Wu Hao, He Chang-Yi, Zhu Dong-Li, Chen Xiao-Feng, Guo Yan, Yang Zhi, Yang Tie-Lin

Abstract excerpt

The synovium is an important component of any synovial joint and is the major target tissue of inflammatory arthritis. However, the multi-omics landscape of synovium required for functional inference is absent from large-scale resources. Here we integrate genomics with transcriptomics and chromatin accessibility features of human synovium in up to 245 arthritic patients, to characterize the landscape of genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38360850
DOI: 10.1038/s41467-024-45652-x
PMCID: PMC10869817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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