Single-Cell Transcriptomics Reveals Depletion and Dysregulation of Mycobacterium tuberculosis –Specific Th1 and Th17 Cells Early After Acquisition of Human Immunodeficiency Virus

Abstract excerpt

Human immunodeficiency virus (HIV) significantly increases the risk of developing tuberculosis (TB) and is associated with impaired CD4 T-cell responses to Mycobacterium tuberculosis (Mtb). We evaluated the frequency and functional capacity of Mtb-specific CD4 T cells in individuals with and without HIV using flow cytometry and performed single-cell RNA sequencing on these cells longitudinally in a subset of...

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