Article
The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection.
Frontiers in immunology - 1 Jan 2021
Le Hingrat Quentin, Sereti Irini, Landay Alan L, Pandrea Ivona, Apetrei Cristian
Abstract excerpt
CD4+ T-cell depletion is pathognomonic for AIDS in both HIV and simian immunodeficiency virus (SIV) infections. It occurs early, is massive at mucosal sites, and is not entirely reverted by antiretroviral therapy (ART), particularly if initiated when T-cell functions are compromised. HIV/SIV infect and kill activated CCR5-expressing memory and effector CD4+ T-cells from the intestinal lamina propria. Acute CD4+...
Topics
- Animals
- Bacterial Translocation
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- Gastrointestinal Microbiome
- HIV
- HIV Infections
- Haplorhini
- Host-Pathogen Interactions
- Humans
- Immunity, Mucosal
- Immunocompromised Host
- Inflammation Mediators