Article

Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19

2023-11-28

Abstract excerpt

<title>Abstract</title> <p>The long-term physiological consequences of SARS-CoV-2, termed Post-Acute Sequelae of COVID-19 (PASC), are rapidly evolving into a major public health concern. The underlying cellular and molecular etiology remain poorly defined but growing evidence links PASC to abnormal immune responses and/or poor organ recovery post-infection. Yet, the precise mechanisms driving non-resolving inflam...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1fde1487-949d-5e54-b520-b1a1d2774e1e
DOI: 10.21203/rs.3.rs-3587418/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19DOI 10.21203/rs.3.rs-3587418/v1Read

Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19Semantic proximity Read

Immune Signatures of SARS-CoV-2 Infection Resolution in Human Lung TissuesSemantic proximity Read

Pulmonary Mesenchymal Stem Cells in Mild Cases of COVID-19 Are Dedicated to Proliferation; In Severe Cases, They Control Inflammation, Make Cell Dispersion, and Tissue RegenerationSemantic proximity Read

Immune checkpoint dysregulation in COVID-19 pathogenesis and disease severity.Semantic proximity Read

Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lungSemantic proximity Read

T-cell Multiomic Analysis Identifies Subsets and Mechanisms of Interaction with Epithelial Cells in Idiopathic Pulmonary FibrosisSemantic proximity Read

Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19Semantic proximity Read

Abnormal respiratory progenitors in fibrotic lung injurySemantic proximity Read

Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolutionSemantic proximity Read

Integrated EVLP and single-cell profiling uncovers aberrant activation of tissue-resident lymphocytes and pro-fibrotic GZMK⁺ CD8 T cells in IPFSemantic proximity Read

Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19Semantic proximity Read

Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regenerationSemantic proximity Read