Article
Supranormal thymic output up to 2 decades after HIV-1 infection.
AIDS (London, England) - 13 Mar 2016
Aguilera-Sandoval Christian R, Yang Otto O, Jojic Nebojsa, Lovato Pietro, Chen Diana Y, Boechat Maria Ines, Cooper Paige, Zuo Jun, Ramirez Christina, Belzer Marvin, Church Joseph A, Krogstad Paul
Abstract excerpt
OBJECTIVES: AIDS is caused by CD4 T-cell depletion. Although combination antiretroviral therapy can restore blood T-cell numbers, the clonal diversity of the reconstituting cells, critical for immunocompetence, is not well defined. METHODS: We performed an extensive analysis of parameters of thymic function in perinatally HIV-1-infected (n = 39) and control (n = 28) participants ranging from 13 to 23 years of...
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