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Article

Progenitor and Terminal Subsets of CD8 <sup>+</sup> T Cells Cooperate to Contain Chronic Viral Infection

29 Nov 2012

Abstract excerpt

Chronic infections strain the regenerative capacity of antiviral T lymphocyte populations, leading to failure in long-term immunity. The cellular and molecular events controlling this regenerative capacity, however, are unknown. We found that two distinct states of virus-specific CD8(+) T cells exist in chronically infected mice and humans. Differential expression of the T-box transcription factors T-bet and...

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PMID: 23197535
DOI: 10.1126/science.1229620

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