Article

Structures of aberrant spliceosome intermediates on their way to disassembly

2024-09-14

Abstract excerpt

Intron removal during pre-mRNA splicing is of extraordinary complexity and its disruption causes a vast number of genetic diseases in humans 1 . While key steps of the canonical spliceosome cycle have been revealed by combined structure-function analyses 2,3 , structural information on an aberrant spliceosome committed to premature disassembly is not available. Here, we report two cryo-EM structures of post-B a...

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Literature Corpus work: ab6ec4bc-5742-557a-8d72-e2d198e4137d
DOI: 10.1101/2024.09.13.612651

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