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Article

Structure of the yeast spliceosomal postcatalytic P complex.

Science (New York, N.Y.) - 8 Dec 2017

Liu Shiheng, Li Xueni, Zhang Lingdi, Jiang Jiansen, Hill Ryan C, Cui Yanxiang, Hansen Kirk C, Zhou Z Hong, Zhao Rui

Abstract excerpt

The spliceosome undergoes dramatic changes in a splicing cycle. Structures of B, Bact, C, C*, and intron lariat spliceosome complexes revealed mechanisms of 5'-splice site (ss) recognition, branching, and intron release, but lacked information on 3'-ss recognition, exon ligation, and exon release. Here we report a cryo-electron microscopy structure of the postcatalytic P complex at 3.3-angstrom resolution,...

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Identifiers

PMID: 29146870
DOI: 10.1126/science.aar3462
PMCID: PMC5828012

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Source receipt: pubmed, retrieved 7 Sept 2026.

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