Article

Splicing quality control mediated by DHX15 and its G-patch activator, SUGP1

2022-11-15

Abstract excerpt

<h4>ABSTRACT</h4> Pre-mRNA splicing is surveilled at different stages by quality control (QC) mechanisms. The leukemia-associated DExH-box family helicase h DHX15/ sc Prp43, is known to disassemble spliceosomes after splicing. Here, using rapid protein depletion and analysis of nascent and mature RNA to enrich for direct effects, we identified a widespread splicing QC function for DHX15 in human cells, consiste...

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Identifiers and source

Literature Corpus work: 93a93db8-6579-5875-a1ee-585ebec82e10
DOI: 10.1101/2022.11.14.516533

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