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Article

Single-Cell cis-Mendelian Randomization Reveals Cell-Specific Genetic Mechanisms Underlying Atopic Dermatitis.

International journal of molecular sciences - 27 Feb 2026

Antonatos Charalabos, Vasilopoulos Yiannis

Abstract excerpt

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex and highly polygenic genetic architecture, in which immune-mediated mechanisms play a central role. Here, we integrated single-cell cis-expression quantitative trait loci from 14 immune cell types with AD GWAS summary statistics using a two-sample Mendelian Randomization (MR) framework to resolve cell-specific genetically mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41828452
DOI: 10.3390/ijms27052226
PMCID: PMC12985171

Genes

IL2RA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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