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DNA stimulates SIRT6 to mono-ADP-ribosylate proteins within histidine repeats

2024-07-31

Abstract excerpt

Sirtuins are the NAD + -dependent class III lysine deacylases (KDACs). Members of this family have been linked to longevity and a wide array of different diseases, motivating the pursuit of sirtuin modulator compounds. Sirtuin 6 (SIRT6) is a primarily nuclear KDAC that deacetylates histones to facilitate gene repression. In addition to this canonical post-translational modification (PTM) “eraser” function, SIRT6...

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Identifiers and source

Literature Corpus work
ab5829d5-4ce4-57de-a3fc-676e60f3fa12
DOI
10.1101/2024.07.31.606047
Open publication

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DNA stimulates SIRT6 to mono-ADP-ribosylate proteins within histidine repeatsDOI 10.1101/2024.07.31.606047
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