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Article

Sirtuins 1 and 2 Are Universal Histone Deacetylases.

ACS chemical biology - 18 Mar 2016

Hsu Willie W, Wu Bo, Liu Wenshe R

Abstract excerpt

Lysine acetylation serves as an epigenetic marker for myriad cellular processes, such as signaling, differentiation, DNA repair, angiogenesis, and the like. Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD(+)-dependent histone deacetylases that operate as post-translational regulators for the deacetylation of acetyllysine. Here, we discuss the ability for SIRT1 and SIRT2 to deacetylate monoacetylated histone H3 on...

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Source

Identifiers

PMID: 26820517
DOI: 10.1021/acschembio.5b00886

Genes

SIRT1
SIRT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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