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The Biochemistry of Sirtuins

7 Apr 2006

Abstract excerpt

Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2'-O-acetyl-ADP-ribose. In multicellular organisms, sirtuins deacetylate histones and transcription...

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PMID: 16756498
DOI: 10.1146/annurev.biochem.74.082803.133500

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