Article

Homocitrullinated Peptides Drive Pro-Inflammatory T-Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

2025-10-31

Abstract excerpt

<h4>Objective</h4> Anti-homocitrullinated protein/peptide antibodies (AHCPA) are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated antigens. However, T-cell responses to homocitrullinated peptides remain largely unexplored. We investigated these responses in a humanized HLA-DR4-transgenic (DR4tg) mouse model of RA, which e...

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Literature Corpus work: ab543dbd-d0fb-5502-b26e-0782ce83ea66
DOI: 10.1101/2025.10.30.685402

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