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Article

Are Th17 cells an appropriate new target in the treatment of rheumatoid arthritis?

Clinical and translational science - 1 Dec 2010

Kato Hiroshi, Fox David A

Abstract excerpt

Th17 cells play crucial roles not only in host defense but also in many human autoimmune diseases and corresponding animal models. Although many of the fundamental principles regarding Th17 biology have been rapidly elucidated in mice, there remain numerous controversies regarding the differentiation, plasticity, and pathogenicity of human Th17 cells. In this review, we consider these open questions in comparison...

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Identifiers

PMID: 21167010
DOI: 10.1111/j.1752-8062.2010.00233.x
PMCID: PMC3057561

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