Article
Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis.
Journal of translational medicine - 14 Nov 2019
Spiering Rachel, Jansen Manon A A, Wood Matthew J, Fath Anshorulloh A, Eltherington Oliver, Anderson Amy E, Pratt Arthur G, van Eden Willem, Isaacs John D, Broere Femke, Hilkens Catharien M U
Abstract excerpt
BACKGROUND: Autologous tolerogenic dendritic cells (tolDC) are a promising therapeutic strategy for inflammatory arthritis (IA) as they can regulate autoantigen-specific T cell responses. Here, we investigated two outstanding priorities for clinical development: (i) the suitability of using heat-shock proteins (HSP), abundant in inflamed synovia, as surrogate autoantigens to be presented by tolDC and (ii)...
Topics
- Aged
- Arthritis, Psoriatic
- Arthritis, Rheumatoid
- Bystander Effect
- Case-Control Studies
- Cell Proliferation
- Dendritic Cells
- Epitopes
- Female
- Heat-Shock Proteins
- Humans
- Immune Tolerance
- Inflammation