Article

Immune Responses Targeting Homocitrullinated Peptides Drive Rheumatoid Arthritis-like Pathology in HLA-DR4 Transgenic Mice

2025-09-20

Abstract excerpt

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. A hallmark feature of RA is the presence of anti-citrullinated protein autoantibodies (ACPAs), which have been extensively studied in disease pathogenesis. The development of these autoantibodies is strongly associated with the expression of HLA-DR4, containing the shared...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae6626d7-a146-5bf4-b03e-3754c689c75a
DOI: 10.1101/2025.09.17.676523

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune Responses Targeting Homocitrullinated Peptides Drive Rheumatoid Arthritis-like Pathology in HLA-DR4 Transgenic MiceDOI 10.1101/2025.09.17.676523Read

Homocitrullinated Peptides Drive Pro-Inflammatory T-Cell Responses in a Humanized Mouse Model of Rheumatoid ArthritisSemantic proximity Read

Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic miceSemantic proximity Read

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.Semantic proximity Read

Animal Models in Rheumatoid Arthritis: Is There a Correlation Between Autoantibodies in Human Pathology and Animal Models?Semantic proximity Read

Peptidylarginine Deiminase Autoimmunity and the Development of Anti-Citrullinated Protein Antibody in Rheumatoid Arthritis: The Hapten-Carrier Model.Semantic proximity Read

In Rheumatoid Arthritis Patients, HLA-DRB1*04:01 and Rheumatoid Nodules Are Associated With ACPA to a Particular Fibrin EpitopeSemantic proximity Read

A new humanized TCR transgenic mouse model to study citrullinated tenascin C reactive T cells relevant to rheumatoid arthritisSemantic proximity Read

Immune tolerance induction with multiepitope peptide derived from citrullinated autoantigens attenuates arthritis manifestations in adjuvant arthritis rats.Semantic proximity Read

The immunopathogenesis of rheumatoid arthritis.Semantic proximity Read

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damageSemantic proximity Read

Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiologySemantic proximity Read

Autoantibodies to Posttranslational Modifications in Rheumatoid ArthritisSemantic proximity Read