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Persistent circulating autoreactive PD1⁺TIGIT⁺ peripheral helper T cells reflect synovial lymphoid activity and poor response to conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis

2026-07-30

Abstract excerpt

<h4>Objective</h4> In the first year after onset of the autoimmune disease RA (RA), 40-60% do not achieve remission on conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). To understand how autoreactive T cells may contribute to unstable or non-remission, we studied CD4+ T cells, including those recognising citrullinated (Cit) vimentin in participants with RA. <h4>Methods</h4> Two cohorts of...

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Literature Corpus work
c5e6cc24-0e62-5ff0-ac3a-93b1f64c099a
DOI
10.64898/2026.07.28.740434
Open publication

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Persistent circulating autoreactive PD1⁺TIGIT⁺ peripheral helper T cells reflect synovial lymphoid activity and poor response to conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritisDOI 10.64898/2026.07.28.740434
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