Article

Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

2024-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Human immune system (HIS) mice constructed in various ways are widely used for investigations of human immune responses to pathogens, transplants and immunotherapies. In HIS mice that generate T cells de novo from hematopoietic progenitors, T cell-dependent multisystem autoimmune disease occurs, most rapidly when the human T cells develop in the native NOD.Cg- Prkdc scid Il2rg tm1Wjl (NSG) mou...

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Literature Corpus work: dc6b59d9-95fe-5ec5-a92d-438dc076e783
DOI: 10.1101/2024.05.02.591692

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