Article

Ankrd26 is critical for cell differentiation and cancer-linked mutations affect its key properties

2021-05-20

Abstract excerpt

Derailed signaling originating from the plasma membrane is associated with many types of cancer. Different human cancers and thrombocytopenia are linked to ANKRD26 mutations. We unveil that Ankrd26 is a plasma membrane-localized protein forming nanoclusters and that Ankrd26 is critical for retinoic acid/BDNF-induced neuroblastoma differentiation. An N-terminal amphipathic structure lacking in an AML-associated An...

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Literature Corpus work: ab53c84c-87a9-5550-94c2-195d92cdab0e
DOI: 10.1101/2021.05.19.444897

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