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Article

5’UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemia

18 Jan 2017

Abstract excerpt

Thrombocytopenia 2 (THC2) is an inherited disorder caused by monoallelic single nucleotide substitutions in the 5'UTR of the ANKRD26 gene. Patients have thrombocytopenia and increased risk of myeloid malignancies, in particular, acute myeloid leukemia (AML). Given the association of variants in the ANKRD26 5'UTR with myeloid neoplasms, we investigated whether, and to what extent, mutations in this region...

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PMID: 28100250
DOI: 10.1186/s13045-016-0382-y

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