Article

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis

2022-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Sustained ANKRD26 expression associated with germline ANKRD26 mutations causes Thrombocytopenia 2 (THC2), an inherited platelet disorder associated with leukemia predisposition. Some of those patients present also erythrocytosis and/or leukocytosis. Using multiple human-relevant in vitro models (cell lines, primary patient cells and patient-derived iPSCs) we demonstrate for the first time that...

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Literature Corpus work: 31d4e078-3cbb-50b4-98cc-fffd03b46231
DOI: 10.1101/2022.09.01.506160

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