Article
Structural basis of diverse membrane target recognitions by ankyrins.
eLife - 10 Nov 2014
Wang Chao, Wei Zhiyi, Chen Keyu, Ye Fei, Yu Cong, Bennett Vann, Zhang Mingjie
Abstract excerpt
Ankyrin adaptors together with their spectrin partners coordinate diverse ion channels and cell adhesion molecules within plasma membrane domains and thereby promote physiological activities including fast signaling in the heart and nervous system. Ankyrins specifically bind to numerous membrane targets through their 24 ankyrin repeats (ANK repeats), although the mechanism for the facile and independent evolution...
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