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Article

Modeling ANKRD26 5'-UTR mutation-related thrombocytopenia.

Disease models & mechanisms - 1 Apr 2025

Zheng Liang, Wu Zhijian, Yada Noritaka, Liu Szumam, Lin Cindy, Bignotti Antonia, Zhao Xinyang, Zheng X Long

Abstract excerpt

Mutations in the 5'-untranslated region (5'-UTR) of ankyrin repeat domain-containing protein 26 (ANKRD26) are associated with hereditary thrombocytopenia 2 (THC2). However, the causative role of these mutations and the mechanisms underlying THC2 are not fully established. Here, we report, for the first time, that zebrafish carrying a deletion of two nucleotides (Δ2) in the 5'-UTR of ankrd26 recapitulate some of...

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PMID: 40170493
DOI: 10.1242/dmm.052222
PMCID: PMC12067082

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