Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis

16 Feb 2023

Abstract excerpt

Sustained ANKRD26 expression associated with germline ANKRD26 mutations causes thrombocytopenia 2 (THC2), an inherited platelet disorder associated with a predisposition to leukemia. Some patients also present with erythrocytosis and/or leukocytosis. Using multiple human-relevant in vitro models (cell lines, primary patients' cells and patient-derived induced pluripotent stem cells) we demonstrate for the first...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment
Share to Platelet Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36794499
DOI: 10.3324/haematol.2022.282049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesisPMID 36794499Read ↗

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesisSemantic proximity Read ↗

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.Semantic proximity Read ↗

ANKRD26-Related Thrombocytopenia and Predisposition to Myeloid Neoplasms.Semantic proximity Read ↗

Prevalence and natural history of variants in the ANKRD26 gene: a short review and update of reported cases.Semantic proximity Read ↗

Mutations in ANKRD26 are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families.Semantic proximity Read ↗

Generation of the human induced pluripotent stem cell line (SHAMUi001-A) carrying the heterozygous c.-128G>T mutation in the 5'-UTR of the ANKRD26 gene.Semantic proximity Read ↗

5’UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemiaSemantic proximity Read ↗

Inherited thrombocytopenia associated with a variant in the FLI1 binding site in the 5' UTR of ANKRD26.Semantic proximity Read ↗

Analysis of clinical characteristics and treatment efficacy in two pediatric cases of ANKRD26-related thrombocytopenia.Semantic proximity Read ↗

Clinic, pathogenic mechanisms and drug testing of two inherited thrombocytopenias, ANKRD26-related Thrombocytopenia and MYH9-related diseases.Semantic proximity Read ↗

A new family with a germline<i>ANKRD26</i>mutation and predisposition to myeloid malignanciesSemantic proximity Read ↗

Mutations in the 5' UTR of ANKRD26, the ankirin repeat domain 26 gene, cause an autosomal-dominant form of inherited thrombocytopenia, THC2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.