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Article

Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling.

Journal of neurochemistry - 1 May 2011

Georgieva Maya V, de Pablo Yolanda, Sanchis Daniel, Comella Joan X, Llovera Marta

Abstract excerpt

The nerve growth factor receptor TrkA (tropomyosin-related kinase receptor) participates in the survival and differentiation of several neuronal populations. The C-terminal tail of TrkA contains a PPXY motif, the binding site of the E3 ubiquitin-ligase Nedd4-2 (neural precursor cell expressed, developmentally down-regulated 4-2). In order to analyze the role of Nedd4-2 ubiquitination on TrkA function, we...

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Identifiers

PMID: 21332718
DOI: 10.1111/j.1471-4159.2011.07218.x

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