Article
Joint testing of genotype and ancestry association in admixed families.
Genetic epidemiology - 1 Dec 2010
Tang Hua, Siegmund David O, Johnson Nicholas A, Romieu Isabelle, London Stephanie J
Abstract excerpt
Current genome-wide association studies (GWAS) often involve populations that have experienced recent genetic admixture. Genotype data generated from these studies can be used to test for association directly, as in a non-admixed population. As an alternative, these data can be used to infer chromosomal ancestry, and thus allow for admixture mapping. We quantify the contribution of allele-based and ancestry-based...
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