Article

CYP2J2 and EETs Protect Against Pulmonary Hypertension with Lung Ischemia-Reperfusion Injury In Vivo and In Vitro

2021-09-07

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert anti-inflammatory, anti-apoptotic, pro-proliferative, and antioxidant effects on the cardiovascular system. However, the role of CYP2J2 and EETs in pulmonary arterial hypertension (PAH) with lung ischemia-reperfusion injury (LIRI) remains uncl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab2ae21d-e5f5-53cd-ad80-7c4a55d92097
DOI: 10.21203/rs.3.rs-855996/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CYP2J2 and EETs Protect Against Pulmonary Hypertension with Lung Ischemia-Reperfusion Injury In Vivo and In VitroDOI 10.21203/rs.3.rs-855996/v1Read

Pharmacological Activation Of Aldehyde Dehydrogenase 2 Protects Against Heatstroke-Induced Acute Lung Injury by Modulating Oxidative Stress and Endothelial Dysfunction.Semantic proximity Read

The role and mechanism of NRF2 in endothelial cells and smooth muscle cells of pulmonary arterySemantic proximity Read

Mesenchymal stem cell-based angiotensin-converting enzyme 2 in treatment of acute lung injury rat induced by bleomycin.Semantic proximity Read

MSCs with ACE II gene affect apoptosis pathway of acute lung injury induced by bleomycin.Semantic proximity Read

CYP2J2 - regulation, function and polymorphism.Semantic proximity Read

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2αSemantic proximity Read

Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j.Semantic proximity Read

Therapeutic effect of human umbilical cord mesenchymal stem cells modified by angiotensin-converting enzyme 2 gene on bleomycin-induced lung fibrosis injury.Semantic proximity Read

CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype.Semantic proximity Read

A novel polymorphism of the CYP2J2 gene is associated with coronary artery disease in Uygur population in China.Semantic proximity Read

The ET-1-mediated carbonylation and degradation of ANXA1 induce inflammatory phenotype and proliferation of pulmonary artery smooth muscle cells in HPS.Semantic proximity Read

Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.Semantic proximity Read