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Article

CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2014

Abraham Nader G, Sodhi Komal, Silvis Anne M, Vanella Luca, Favero Gaia, Rezzani Rita, Lee Craig, Zeldin Darryl C, Schwartzman Michal L

Abstract excerpt

Obesity is a global epidemic and a common risk factor for endothelial dysfunction and the subsequent development of diabetes mellitus and vascular diseases such as hypertension. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-derived metabolites of arachidonic acid that contribute to vascular protection by stimulating vasodilation and inhibiting inflammation. Heme oxygenase-1 is a stress response...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25245389
DOI: 10.1161/HYPERTENSIONAHA.114.03884
PMCID: PMC4230994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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