Article

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α

2024-02-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> In hypoxic and pseudohypoxic rodent models of pulmonary arterial hypertension (PAH), hypoxia-inducible factor (HIF) inhibition reduces disease severity. However, HIF activation alone, due to genetic alterations or use of inhibitors of prolyl hydroxylase domain (PHD) enzymes, has not been definitively shown to cause PAH in humans, indicating the involvement of other mechanism...

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Literature Corpus work: 626ee421-1c41-5703-9bfb-3fa2b5b0a22b
DOI: 10.1101/2024.02.01.578286

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