Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j.

American journal of respiratory cell and molecular biology - 1 May 2015

Beloiartsev Arkadi, da Glória Rodrigues-Machado Maria, Zhou Guo Ling, Tan Timothy C, Zazzeron Luca, Tainsh Robert E, Leyton Patricio, Jones Rosemary C, Scherrer-Crosbie Marielle, Zapol Warren M

Abstract excerpt

Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to the regulation of pulmonary vascular tone and hypoxic pulmonary vasoconstriction. We investigated whether the attenuated acute vasoconstrictor response to hypoxic exposure of Cyp2j(-/-) mice would protect these mice again...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arterial Pressure
Share to Cytochrome P450 Family 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epoxide Hydrolases

Share to Hemoglobins

Share to Hypertension, Pulmonary

Share to Hypoxia

Share to Pulmonary Artery

Share to Vascular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 25233285
DOI: 10.1165/rcmb.2013-0482OC
PMCID: PMC4491134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25233285-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j.PMID 25233285Read ↗

Hypoxia‐induced pulmonary hypertension upregulates eNOS and TGF‐β contributing to sex‐linked differences in BMPR2+/R899X mutant miceSemantic proximity Read ↗

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.Semantic proximity Read ↗

Pulmonary Hypertension Induced by Right Pulmonary Artery Occlusion: Hemodynamic Consequences of Bmpr2 Mutation.Semantic proximity Read ↗

Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice.Semantic proximity Read ↗

CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype.Semantic proximity Read ↗

CYP2J2 - regulation, function and polymorphism.Semantic proximity Read ↗

The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice.Semantic proximity Read ↗

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature.Semantic proximity Read ↗

Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice.Semantic proximity Read ↗

Interaction between Bone Morphogenetic Protein Receptor Type 2 and Estrogenic Compounds in Pulmonary Arterial HypertensionSemantic proximity Read ↗

Transcriptomic modifications in developmental cardiopulmonary adaptations to chronic hypoxia using a murine model of simulated high-altitude exposureSemantic proximity Read ↗

CYP2J2 and EETs Protect Against Pulmonary Hypertension with Lung Ischemia-Reperfusion Injury In Vivo and In VitroSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.