Article

Somatic chromosomal number alterations affecting driver genes inform <i>in-vitro</i> and clinical drug response in high-grade serous ovarian cancer

2020-10-04

Abstract excerpt

The genomic complexity and heterogeneity of high-grade serous ovarian cancer (HGSOC) has hampered the realisation of successful therapies and effective personalised treatment is an unmet clinical need. Here we show that primary HGSOC spheroid models can be used to predict drug response and use them to demonstrate that somatic copy number alterations (SCNAs) in frequently amplified HGSOC cancer genes significantly...

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Literature Corpus work: ab22b999-106c-5733-a718-dde29562455d
DOI: 10.1101/2020.10.04.325365

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Somatic chromosomal number alterations affecting driver genes inform <i>in-vitro</i> and clinical drug response in high-grade serous ovarian cancerDOI 10.1101/2020.10.04.325365Read

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