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Article

Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer.

Nature communications - 15 Feb 2017

Delaney Joe Ryan, Patel Chandni B, Willis Katelyn McCabe, Haghighiabyaneh Mina, Axelrod Joshua, Tancioni Isabelle, Lu Dan, Bapat Jaidev, Young Shanique, Cadassou Octavia, Bartakova Alena, Sheth Parthiv, Haft Carley, Hui Sandra, Saenz Cheryl, Schlaepfer David D, Harismendy Olivier, Stupack Dwayne G

Abstract excerpt

Identification of specific oncogenic gene changes has enabled the modern generation of targeted cancer therapeutics. In high-grade serous ovarian cancer (OV), the bulk of genetic changes is not somatic point mutations, but rather somatic copy-number alterations (SCNAs). The impact of SCNAs on tumour biology remains poorly understood. Here we build haploinsufficiency network analyses to identify which SCNA...

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PMID: 28198375
DOI: 10.1038/ncomms14423
PMCID: PMC5316854

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BECN1

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