Article
Copy number signatures and mutational processes in ovarian carcinoma.
Nature genetics - 1 Sept 2018
Macintyre Geoff, Goranova Teodora E, De Silva Dilrini, Ennis Darren, Piskorz Anna M, Eldridge Matthew, Sie Daoud, Lewsley Liz-Anne, Hanif Aishah, Wilson Cheryl, Dowson Suzanne, Glasspool Rosalind M, Lockley Michelle, Brockbank Elly, Montes Ana, Walther Axel, Sundar Sudha, Edmondson Richard, Hall Geoff D, Clamp Andrew, Gourley Charlie, Hall Marcia, Fotopoulou Christina, Gabra Hani, Paul James, Supernat Anna, Millan David, Hoyle Aoisha, Bryson Gareth, Nourse Craig, Mincarelli Laura, Sanchez Luis Navarro, Ylstra Bauke, Jimenez-Linan Mercedes, Moore Luiza, Hofmann Oliver, Markowetz Florian, McNeish Iain A, Brenton James D
Abstract excerpt
The genomic complexity of profound copy number aberrations has prevented effective molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy number signatures from shallow whole-genome sequencing of 117 high-grade serous ovarian cancer (HGSOC) cases, which were validated on 527 independent cases. We show that HGSOC comprises a continuum of genomes shaped by multiple mutational...
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