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Article

Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes.

Oncotarget - 10 Nov 2015

Hunter Sally M, Anglesio Michael S, Ryland Georgina L, Sharma Raghwa, Chiew Yoke-Eng, Rowley Simone M, Doyle Maria A, Li Jason, Gilks C Blake, Moss Phillip, Allan Prue E, Stephens Andrew N, Huntsman David G, deFazio Anna, Bowtell David D, Gorringe Kylie L, Campbell Ian G

Abstract excerpt

Low grade serous ovarian tumours are a rare and under-characterised histological subtype of epithelial ovarian tumours, with little known of the molecular drivers and facilitators of tumorigenesis beyond classic oncogenic RAS/RAF mutations. With a move towards targeted therapies due to the chemoresistant nature of this subtype, it is pertinent to more fully characterise the genetic events driving this tumour...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26506417
DOI: 10.18632/oncotarget.5438
PMCID: PMC4741956

Genes

NRAS
BRAF
ERBB2
KRAS
HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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