Article
Genomic analysis of low-grade serous ovarian carcinoma to identify key drivers and therapeutic vulnerabilities.
The Journal of pathology - 1 Jan 2021
Cheasley Dane, Nigam Abhimanyu, Zethoven Magnus, Hunter Sally, Etemadmoghadam Dariush, Semple Timothy, Allan Prue, Carey Mark S, Fernandez Marta L, Dawson Amy, Köbel Martin, Huntsman David G, Le Page Cécile, Mes-Masson Anne-Marie, Provencher Diane, Hacker Neville, Gao Yunkai, Bowtell David, deFazio Anna, Gorringe Kylie L, Campbell Ian G
Abstract excerpt
Low-grade serous ovarian carcinoma (LGSOC) is associated with a poor response to existing chemotherapy, highlighting the need to perform comprehensive genomic analysis and identify new therapeutic vulnerabilities. The data presented here represent the largest genetic study of LGSOCs to date (n = 71), analysing 127 candidate genes derived from whole exome sequencing cohorts to generate mutation and copy-number...
Topics
Join the communities discussing this publication.