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Article

A Genomically Characterized Collection of High-Grade Serous Ovarian Cancer Xenografts for Preclinical Testing.

The American journal of pathology - 1 May 2018

Cybulska Paulina, Stewart Jocelyn M, Sayad Azin, Virtanen Carl, Shaw Patricia A, Clarke Blaise, Stickle Natalie, Bernardini Marcus Q, Neel Benjamin G

Abstract excerpt

High-grade serous ovarian cancer (HGSC) is the leading cause of morbidity and mortality from gynecologic malignant tumors. Overall survival remains low because of the nearly ubiquitous emergence of platinum resistance and the paucity of effective next-line treatments. Current cell culture-based models show limited similarity to HGSC and are therefore unreliable predictive models for preclinical evaluation of...

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PMID: 29458007
DOI: 10.1016/j.ajpath.2018.01.019

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