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Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer

26 Oct 2022

Abstract excerpt

Chromosomal instability is a major challenge to patient stratification and targeted drug development for high-grade serous ovarian carcinoma (HGSOC). Here we show that somatic copy number alterations (SCNAs) in frequently amplified HGSOC cancer genes significantly correlate with gene expression and methylation status. We identify five prevalent clonal driver SCNAs (chromosomal amplifications encompassing MYC,...

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PMID: 36289203
DOI: 10.1038/s41467-022-33870-0

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